上海经济新闻网-以上海经济报道为中心的综合新闻网站

资讯
上海经济国内新闻
社会新闻焦点新闻
企业
企业资讯企业文化
名企风采品牌魅力
财经
国内财经国际财经产经宏观经济
财经观察财经评论金融财富人生
行业
房产动态科技新闻汽车动态
休闲时尚教育动态理财聚焦
股市
股票行情 大盘分析
机构动态 名家文章

Vargatef® plus docetaxel could be an option after failure of immunotherapy in lung cancer

时间:2018-12-16 02:03:43  来源:上海经济新闻网  编辑:yuan4ren

Results from a real-world study1 support a recent update to the ESMO guidelines2 recommending nintedanib (Vargatef) plus docetaxel following first-line chemotherapy (+/- immunotherapy) in advanced NSCLC of adenocarcinoma histology

INGELHEIM, Germany -- (BUSINESS WIRE) --

Boehringer Ingelheim announced today the first interim results of VARGADO, an ongoing non-interventional study in routine clinical practice in Germany evaluating the efficacy and safety of Vargatef® (nintedanib) and docetaxel in patients with stage III/IV locally advanced or metastatic non-small cell lung cancer (NSCLC) of adenocarcinoma histology. The study consists of three cohorts, two of which allow for prior treatment with immune checkpoint inhibitors (ICIs) either in combination with chemotherapy in the first-line or as monotherapy in the second-line of treatment. The interim results from Cohort B (first-line chemotherapy, second-line immune checkpoint inhibitors, third-line Vargatef® plus docetaxel) were presented today at ESMO Immuno-Oncology Congress 2018 in Geneva.1 Despite a limited sample size, the VARGADO study adds to the body of evidence for nintedanib in lung adenocarcinoma following pre-treatment with chemotherapy and ICIs.1,3

The addition of nintedanib to docetaxel has a proven survival benefit as a second-line treatment following chemotherapy in a broad population of lung adenocarcinoma patients.4 However, data are scarce regarding the efficacy and safety of nintedanib in adenocarcinoma patients who have been pre-treated with chemotherapy as well as ICIs.

The results support a recent update to the ESMO guidelines around the treatment of NSCLC, which now recommend nintedanib in combination with chemotherapy as a second-line treatment following prior chemotherapy +/- ICIs.2 A recent report by Jesus Corral et al (WCLC, 2017) which evaluated nintedanib in combination with docetaxel in a similar setting showed similar efficacy and safety information.3

Professor Christian Grohé, Department of Respiratory Diseases, ELK Berlin, said: “As immunotherapy becomes the first-line treatment of choice in advanced lung adenocarcinoma, it’s important to have effective and safe treatment options following immunotherapy. The results from VARGADO provide important evidence supporting the use of nintedanib following initial treatment with immunotherapy and are in line with the recent update to the ESMO guidelines.”

Dr Victoria Zazulina, Global Head of Solid Tumour Oncology, Medicine at Boehringer Ingelheim, said: “With a devastating disease like lung cancer, every option matters. Today’s results provide evidence that nintedanib, when added to docetaxel, is a good therapeutic option for patients that progress following treatment with immunotherapy.”

~ENDS~

Please click on the link for ‘Notes to Editors’ and ‘References’: http://www.boehringer-ingelheim.com/press-release/vargado-data

For more information, please visit: www.boehringer-ingelheim.com

Further Media Channels

www.facebook.com/boehringeringelheim
www.twitter.com/Boehringer
www.youtube.com/user/boehringeringelheim

View source version on businesswire.com: https://www.businesswire.com/news/home/20181214005105/en/

CONTACT:

Boehringer Ingelheim
Corporate Communications
Media + PR
Julia Faaß
Tel.: +49 (6132) 77-95614
Mobil: +49 (151) 15023438
Fax: +49 (6132) 77-6601
Email: press@boehringer-ingelheim.com

更多

精彩图文

网站首页 | 关于我们 | 联系方式 | 招聘信息 | 版权声明 | 网站地图 |

CopyRight 2006---2009  酷6网(北京)信息技术有限公司版权所有